Membrane failures in water and wastewater treatment systems often appear sudden, yet they typically result from progressive and detectable mechanisms. This presentation shares practical insights from conducting comprehensive membrane autopsies designed to uncover the root causes of performance decline. Using standardized procedures and analytical protocols, the work evaluates fouling layers, chemical deposits, structural damage, and operational histories to build a clear diagnostic profile for each membrane element. The results consistently reveal multi‑factor interactions—such as feedwater variability, pretreatment gaps, cleaning inefficiencies, and operational stress—that drive premature failure. By translating autopsy findings into actionable recommendations, utilities have achieved measurable improvements in flux recovery, cleaning effectiveness, and membrane lifespan. Attendees will gain a deeper understanding of how autopsy‑driven decision‑making strengthens asset management, reduces unplanned downtime, and supports more resilient treatment operations.